December - 13 --- Adipose Stem Cell Therapy



Harvest, Separate, Activate and Return (from and to your own body)

Autologous is the term used for stem cells derived from the patient themselves – this is the preferred form of adult stem cell because there is no risk of autoimmune reactions compared to Xenographic or Allogenic cell therapy.

Plant stem cells have had quite a lot of public attention lately, mostly in cosmetics. Currently, they have not shown to be of therapeutic use in improving disease states.

Autologous Adipose Derived Stem Cell use is inherently far safer.

Autologous Adipose Derived Stem Cell (AADSC) extraction and transplants are considered to be the safest form of Stem Cell therapy. This is because it completely negates the potential issue of an autoimmune reaction from a host vs graft reaction when you introduce foreign biological matter into your body. If the cells taken are from your own, then there is no concern.

AADSC therapy does not require any cultivation, multiplication/expansion or re-programming because the volume typically extracted is enough not only for treatment, but also enough to be banked for future use. This removes the contentious issue with regards to damage or alteration of DNA and reduction of viability when cells are expanded. Furthermore, allogenic (from others) sources carry the risk of bacterial, fungal or viral contamination. Proper handling, transport and lab/screening procedures can certainly help to reduce these concerns and in the future we do expect peripheral blood to be a popular alternative to AADSC, but for now, AADSC has been proven to be safe and effective for many health conditions.

Because we use your own unmanipulated cells, there is no risk of an autoimmune reaction and this form of stem cell therapy does not carry the  same safety concerns and controversies that are associated with other forms of Non-Autologous/Allogenic Stem Cell therapies.

 What can stem cells treat? 

Autologous Adipose Derived Adult Mesenchymal Stem Cells(AADSC) [Autologous = From Self; Adipose Derived = from fat; Adult = non embryonic; Mesenchymal = cells that have initially evolved from the mesoderm layer] for general Anti-aging as well as a variety of degenerative diseases and medical conditions. Such Conditions that may show benefit from AADSC include:

    • Autoimmune disorders – MS, ALS, SLE, Atopic Dermatitis
    • Balding
    • Diabetes
    • Fat Stem Cell Face lifts
    • Fat Stem Cell Breast Augmentation
    • Heart Disease
    • Inflammatory bowel diseases: IBS, Crohn’s Disease
    • Kidney disease
    • Knee, joint, Hip, skeletal & spinal cord injuries that involve cartilage, disc, or tendon damage.
    • Liver disease
    • Lung Diseases: Emphysema, Asthma, COPD, Idiopathic Plumonary Fibrosis
    • Macular & Retinal Degeneration + dystrophy, diabetic retinopathy.
    • Stroke
  • WHAT ARE STEM CELLS?Stem cells are biological cells found in all multicellular organisms,  that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells. In mammals, there are two broad types of stem cells: embryonic stem cells and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues.Check out this video produced by the BBC:There are many types of stem cells and they are usually classified by their ability to differentiate to other cells (Totipotent, Pluripotent, Multipotent, unipotenetc.) as well as their origin (animal origin, human embryos, cord blood, bone marrow, fat, re-programmed stem cells etc.). Animal sources are known as Xenographic stem cells and can come from Sheep, Deer, Pigs, Rabbit, cattle etc. Stem cells from other humans are called Allogenic (from teeth, bone marrow or cord blood stem cells etc.). Autologous is the term used for stem cells derived from the patient themselves – this is the preferred form of adult stem cell because there is no risk of autoimmune reactions compared to Xenographic or Allogenic cell therapy. NB. Plant stem cells have had quite a lot of public attention lately, mostly in cosmetics. Currently, they have not shown to be of therapeutic use in improving disease statesListed below are the main groups, with a brief description, of stem cells currently relevant to research and clinical medicine.* Embryonic stem cells: are pluripotent cells with the capacity to form almost every type of cell in the human body. They are derived from the blastocyst (very early stage of embryo development). Sources are almost always allogenic and come from a number of registered cell lines that are commercially available for research purposes. Moral/Ethical and transplant rejection issues have prevented human clinical application.* Induced Pluripotent stem cells: are derived from adult precursor cells which are then manipulated in a laboratory using cellular cultures to induce certain characteristics and pluripotency. They can be autologous or allogenic (from a donor). There are numerous allogenic commercially available cell cultures for rapid expansion of cell population. This does not carry the moral issues involving embryonic cells but does not negate possible transplant rejection potential. Used in research and some countries for treatment, there are concerns that their manipulation can cause possible genetic mutations which has prevented their clinical use (in most countries) in humans to date. Any cells that are manipulated (cultivated or re-programmed) are typically regulated by the medical authorities in most countries.* Mesenchymal stem cells: may be derived from various sources, such as, from self (Autologous) or from a donor (allogenic). Allogenic sources can come from adult bone marrow, blood, adipose tissue or cord blood (collected at birth) or tooth stem cells. There are pros and cons for each source. Bone marrow for example requires a painful extraction process and blood although relatively non-invasive does not yield enough for therapeutic use and requires expansion/proliferation. The preferred method is to get them from the same individual (Autologous) from their adipose tissue since the largest numbers of stem cells are found in fat and that same fat can be used as facial fillers with stem cells. Autologous Adipose Derived Stem Cells also do not require multiplication and very often, enough are collected to be banked for later use and clients get the benefit of a mini lipo under local anesthesia and sedatives.Sources of Autologous Adult Stem Cells There are three accessible sources of autologous adult stem cells in humans:* Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest),* Adipose tissue (lipid cells), which requires extraction by mini-liposuction, and * Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), passed through a machine that extracts the stem cells and returns other portions of the blood to the donor.

    Why Use Adult Stem Cells?

    Early research in Stem Cells involved embryonic cells of fetal origin. This stirred up quite a bit of controversy regarding moral and ethical considerations. (Even though none of the cells were taken from aborted fetuses but actually from unused embryo’s that were to be discarded by IVF clinics). Because of public and political sensitivities to embryonic stem cells, much of the research momentum moved toward adult stem cells. Although not considered as potent as embryonic stem cells, they do have a significant amount of plasticity. With rapidly emerging technology and discoveries, we are finding that adult stem cells can even be reversed to pluripotency. Recently John Gourdon and Shinya Yamanaka won the Nobel science prize for physiology in 2012 for successfully taking mature adult cells and turning it into a stem cell. We believe technology will eventually make embryonic stem cells less relevant in therapy because we will have the ability to induce an equivalent level of pluripotency with adult cells.

    Why use Autologous Adipose Derived Stem Cells rather than Stem Cells derived from bone marrow?

    Adult Stem Cells have no ethical issues and the safest source is Autologous (from self). Bone marrow stem cell transplants have been used successfully for decades (usually for leukemia patients). Unfortunately the extraction process is painful and carries a higher risk of infection. The procedure is also considered to be more dangerous or complicated (requires General Anesthesia) than Autologous Adipose Derived Stem Cells. More importantly, the number of stem cells harvested from fat is significantly higher than from bone marrow extraction. For your reference, the typical yield is not more than a few million cells (which is why expansion to therapeutic numbers, about 35-50 million is required). In contrast, AADSC extraction yields anywhere from 400-800 million cells. With our pre-treatment stem cell boosting protocol, we are now averaging over a billion cells per patient with one patient getting over 2 billion.

    Autologous Adipose Derived Stem Cell use is inherently far safer

    Autologous Adipose Derived Stem Cell (AADSC) extraction and transplants are considered to be the safest form of Stem Cell therapy. This is because it completely negates the potential issue of an autoimmune reaction from a host vs graft reaction when you introduce foreign biological matter into your body. If the cells taken are from your own, then there is no concern.

    AADSC therapy does not require any cultivation, multiplication/expansion or re-programming because the volume typically extracted is enough not only for treatment, but also enough to be banked for future use. This removes the contentious issue with regards to damage or alteration of DNA and reduction of viability when cells are expanded. Furthermore, allogenic (from others) sources carry the risk of bacterial, fungal or viral contamination. Proper handling, transport and lab/screening procedures can certainly help to reduce these concerns and in the future we do expect peripheral blood to be a popular alternative to AADSC, but for now, AADSC has been proven to be safe and effective for many health conditions.

    Because we use your own unmanipulated cells, there is no risk of an autoimmune reaction and this form of stem cell therapy does not carry the  same safety concerns and controversies that are associated with other forms of Non-Autologous/Allogenic Stem Cell therapies.

    We use a holistic protocol to increase the potency of our Stem Cell therapy.

    The advantage of the concentrated fraction we obtain from adipose tissue consists not only of Meschymal stem cells but also other powerful healing components, such as progenitor cells, pre-mesenchymal stem cells, growth factor and hormone secreting cells and immune modulating cells etc. This mixture is known as the Stromal Fraction. To further add potency, we also extract the stromal fraction from your own blood and mix them together with the stromal fraction from your Adipose tissue.  This synergistic combination is further activated by a low level laser to significantly increase viability and activity.

    This Orchestral mix of regenerative cells work in synergy to boost overall regenerative ability. This may help explain why some studies solely using cultured single lineage stem cells have shown disappointing results whereas stromal fractions have had much more encouraging results. An analogy would be the

    stem cell being the conductor and the other hundreds of regenerative components make up the wonder of an Orchestra. Everything in our body works in ‘concert’ with many other ‘bioactive mediators’ to achieve a regenerative result that surpasses any single component on its own.